Article, 2023
Dostarlimab for Primary Advanced or Recurrent Endometrial Cancer
NEW ENGLAND JOURNAL OF MEDICINE, ISSN 0028-4793, 0028-4793, Volume 388, 23, Pages 2145-2158, 10.1056/NEJMoa2216334
Contributors
Mirza, M. R. (Corresponding author) [1] [2] [3] Chase, D. 0000-0003-1075-4108 [4] [5] [6] [7] Slomovitz, B. M. [8] [9] [10] Christensen, R. dePont [11] Novak, Z. [12] Black, D. [13] [14] [15] Gilbert, Lucy 0000-0001-8605-5472 [16] Sharma, S. [17] Valabrega, G. [18] [19] [20] Landrum, L. M. [21] [22] Hanker, L. C. [23] [24] Stuckey, A. [25] Boere, I. [26] [27] [28] Gold, M. A. 0000-0002-0605-1971 [29] Auranen, A. [30] [31] Pothuri, Bhavana [32] Cibula, D. [33] [34] Mccourt, C. [35] Raspagliesi, F. 0000-0001-8953-1657 [36] [37] Shahin, M. S. [38] Gill, S. E. [39] Monk, Bradley J. [40] [41] Buscema, J. [42] Herzog, Thomas [43] [44] Copeland, L. J. [44] [45] [46] Tian, M. [47] He, Z. [47] Stevens, Sebastian 0000-0003-4997-2591 [48] Zografos, E. [48] Coleman, Robert 0000-0001-9343-8754 [49] Powell, M. A. [35] [50] [51] RUBY InvestigatorsAffiliations
- [1] Nord Soc Gynaecol Oncol, Clin Trial Unit, Copenhagen, Denmark [NORA names: Miscellaneous; Denmark; Europe, EU; Nordic; OECD];
- [2] Copenhagen Univ Hosp, Dept Oncol, Rigshosp, Copenhagen, Denmark [NORA names: Capital Region of Denmark; Hospital; Denmark; Europe, EU; Nordic; OECD];
- [3] Copenhagen Univ Hosp, Dept Oncol, Rigshosp, Copenhagen, Denmark [NORA names: KU University of Copenhagen; University; Denmark; Europe, EU; Nordic; OECD];
- [4] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA USA [NORA names: United States; America, North; OECD];
- [5] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA USA [NORA names: United States; America, North; OECD];
- [6] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA USA [NORA names: United States; America, North; OECD];
- [7] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA USA [NORA names: United States; America, North; OECD];
- [8] Florida Int Univ, Dept Gynecol Oncol, Mt Sinai Med Ctr, Miami Beach, FL USA [NORA names: United States; America, North; OECD];
- [9] Florida Int Univ, Dept Gynecol Oncol, Mt Sinai Med Ctr, Miami Beach, FL USA [NORA names: United States; America, North; OECD];
- [10] Florida Int Univ, Dept Gynecol Oncol, Mt Sinai Med Ctr, Miami Beach, FL USA [NORA names: United States; America, North; OECD];
- [11] Univ Southern Denmark, Inst Publ Hlth, Res Unit Gen Practice, Odense, Denmark [NORA names: SDU University of Southern Denmark; University; Denmark; Europe, EU; Nordic; OECD];
- [12] Hungarian Natl Inst Oncol, Dept Gynecol, Budapest, Hungary [NORA names: Hungary; Europe, EU; OECD];
- [13] Louisiana State Univ Hlth Shreveport, Dept Obstet & Gynecol, Shreveport, LA USA [NORA names: United States; America, North; OECD];
- [14] Louisiana State Univ Hlth Shreveport, Dept Obstet & Gynecol, Shreveport, LA USA [NORA names: United States; America, North; OECD];
- [15] Willis Knighton Physician Network, Shreveport, LA USA [NORA names: United States; America, North; OECD];
- [16] McGill Univ, Div Gynecol Oncol, Hlth Ctr, Montreal, PQ, Canada [NORA names: Canada; America, North; OECD];
- [17] AMITA Adventist Hinsdale Hosp, Dept Obstet & Gynecol, Hinsdale, IL USA [NORA names: United States; America, North; OECD];
- [18] Univ Turin, AO Ordine Mauriziano, Turin, Italy [NORA names: Italy; Europe, EU; OECD];
- [19] Univ Turin, AO Ordine Mauriziano, Turin, Italy [NORA names: Italy; Europe, EU; OECD];
- [20] Univ Turin, AO Ordine Mauriziano, Turin, Italy [NORA names: Italy; Europe, EU; OECD];
- [21] Indiana Univ, Hlth Simon Canc Ctr, Indianapolis, IN USA [NORA names: United States; America, North; OECD];
- [22] Indiana Univ, Hlth Simon Canc Ctr, Indianapolis, IN USA [NORA names: United States; America, North; OECD];
- [23] Univ Hosp Schleswig Holstein, Dept Gynecol & Obstet, Campus Lubeck, Lubeck, Germany [NORA names: Germany; Europe, EU; OECD];
- [24] Univ Hosp Schleswig Holstein, Dept Gynecol & Obstet, Campus Lubeck, Lubeck, Germany [NORA names: Germany; Europe, EU; OECD];
- [25] Women & Infants Hosp Rhode Isl, Providence, RI USA [NORA names: United States; America, North; OECD];
- [26] Erasmus MC Canc Ctr, Dept Med Oncol, Rotterdam, Netherlands [NORA names: Netherlands; Europe, EU; OECD];
- [27] Erasmus MC Canc Ctr, Dept Med Oncol, Rotterdam, Netherlands [NORA names: Netherlands; Europe, EU; OECD];
- [28] Erasmus MC Canc Ctr, Dept Med Oncol, Rotterdam, Netherlands [NORA names: Netherlands; Europe, EU; OECD];
- [29] Oklahoma Canc Specialists & Res Inst, Tulsa, OK USA [NORA names: United States; America, North; OECD];
- [30] Tampere Univ Hosp, Tampere, Finland [NORA names: Finland; Europe, EU; Nordic; OECD];
- [31] Tampere Univ Hosp, Tampere, Finland [NORA names: Finland; Europe, EU; Nordic; OECD];
- [32] New York Univ Langone Hlth, New York, NY USA [NORA names: Finland; America, North; OECD];
- [33] Charles Univ Prague, Gen Univ Hosp Prague, Fac Med 1, Dept Obstet & Gynecol, Prague, Czech Republic [NORA names: Czechia; America, North; OECD];
- [34] Charles Univ Prague, Gen Univ Hosp Prague, Fac Med 1, Dept Obstet & Gynecol, Prague, Czech Republic [NORA names: Czechia; America, North; OECD];
- [35] Washington Univ, Div Gynecol Oncol, Sch Med, St Louis, MO USA [NORA names: Czechia; America, North; OECD];
- [36] Univ Milan, Gynecol Oncol Unit, Fdn IRCCS Ist Nazl Tumori Milano, Milan, Italy [NORA names: Italy; Europe, EU; OECD];
- [37] Univ Milan, Gynecol Oncol Unit, Fdn IRCCS Ist Nazl Tumori Milano, Milan, Italy [NORA names: Italy; Europe, EU; OECD];
- [38] Thomas Jefferson Univ, Jefferson Hlth, Hanjani Inst Gynecol Oncol, Asplundh Canc Pavil,Sidney Kimmel Med Coll, Willow Grove, PA USA [NORA names: United States; America, North; OECD];
- [39] Nancy N & JC Lewis Canc & Res Pavil, Div Gynecol Oncol, Savannah, GA USA [NORA names: United States; America, North; OECD];
- [40] Creighton Univ, Sch Med, Phoenix, AZ USA [NORA names: United States; America, North; OECD];
- [41] Univ Arizona, HonorHlth Res Inst, Coll Med, Phoenix, AZ USA [NORA names: United States; America, North; OECD];
- [42] Arizona Oncol, Dept Gynecol Oncol, Tucson, AZ USA [NORA names: United States; America, North; OECD];
- [43] Univ Cincinnati, Dept Obstet & Gynecol, Canc Ctr, Cincinnati, OH USA [NORA names: United States; America, North; OECD];
- [44] Ohio State Univ, Comprehens Canc Ctr, Columbus, OH USA [NORA names: United States; America, North; OECD];
- [45] Ohio State Univ, Comprehens Canc Ctr, Columbus, OH USA [NORA names: United States; America, North; OECD];
- [46] Ohio State Univ, Comprehens Canc Ctr, Columbus, OH USA [NORA names: United States; America, North; OECD];
- [47] GSK, Collegeville, PA USA [NORA names: United States; America, North; OECD];
- [48] GSK, London, England [NORA names: United Kingdom; America, North; OECD];
- [49] US Oncol Res, The Woodlands, TX USA [NORA names: United Kingdom; America, North; OECD];
- [50] Washington Univ, NCI, Sponsored NRG Oncol, Sch Med, St Louis, MO USA [NORA names: United States; America, North; OECD];
- [51] Washington Univ, NCI, Sponsored NRG Oncol, Sch Med, St Louis, MO USA [NORA names: United States; America, North; OECD]
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Abstract
BACKGROUND Dostarlimab is an immune-checkpoint inhibitor that targets the programmed cell death 1 receptor. The combination of chemotherapy and immunotherapy may have synergistic effects in the treatment of endometrial cancer.
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