open access publication

Article, Early Access, 2024

Association between type 2 diabetes and depressive symptoms after a 1-year follow-up in an older adult Mediterranean population

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, ISSN 0391-4097, 0391-4097, 10.1007/s40618-023-02278-y

Contributors

Baenas, I. [1] [2] [3] [4] [5] [6] Camacho-Barcia, Lucia 0000-0002-5989-936X [1] [2] [3] [4] [5] [6] Granero, Roser 0000-0001-6308-3198 [3] [4] [5] [6] [7] Razquin, Cristina 0000-0003-3480-2645 [4] [5] [6] [8] Corella, D. [4] [5] [6] [9] Gomez-Martinez, C. [4] [5] [6] [10] [11] Castaner-Nino, O. [4] [5] [12] [13] Martinez, J. Alfredo [4] [5] [6] [8] [14] [15] Alonso-Gomez, a. M. [4] [5] [6] [16] Waernberg, J. [4] [5] [6] [17] [18] Vioque, J. [4] [5] [12] [19] [20] [21] [22] Romaguera, D. [4] [5] [6] [23] [24] Lopez-Miranda, Jose 0000-0002-8844-0718 [4] [5] [6] [25] Estruch, Ramon [1] [4] [5] [6] [26] [27] Tinahones, F. J. [4] [5] [6] [17] [18] [28] [29] Lapetra, J. [4] [5] [6] [30] Serra-Majem, J. L. [4] [5] [6] [31] Cano-Ibanez, N. [4] [5] [12] [32] [33] Tur, Josep A. 0000-0002-6940-0761 [4] [5] [6] [34] Martin-Sanchez, V. [4] [5] [12] [35] Pinto, X. [1] [2] [3] [4] [5] [6] Gaforio, J. J. [4] [5] [12] [36] Matia-Martin, P. [37] Vidal, J. [1] [4] [26] [27] [38] [39] Vazquez, C. [4] [5] [6] [40] [41] Daimiel, L. [4] [5] [6] [42] Ros, E. [1] [4] [5] [6] [26] [27] Jimenez-Murcia, S. [1] [2] [3] [4] [5] [6] Dalsgaard, S. [43] [44] [45] Garcia-Arellano, A. [4] [5] [6] [8] Babio, N. [4] [5] [6] [10] [11] Sorli, J. V. [4] [5] [6] [9] Lassale, Camille 0000-0002-9340-2708 [4] [5] [6] [46] Garcia-de-la-Hera, Manoli 0000-0001-5742-2704 [4] [5] [12] [19] [20] [21] [22] Gomez-Garcia, E. [4] [5] [6] [17] [18] Zulet, M. A. [4] [5] [6] [8] [14] [15] Konieczna, Jadwiga [4] [5] [6] [23] [24] Martin-Pelaez, S. [4] [5] [12] [33] Tojal-Sierra, L. [4] [5] [6] [16] Basterra-Gortari, F. J. [4] [5] [6] [8] [47] [48] [49] de las Heras-delgado, S. [4] [5] [6] [10] [11] Portoles, O. [4] [5] [6] [8] Munoz-Perez, M. a. [50] Arenas-Larriva, A. P. [4] [5] [6] [25] Compan-Gabucio, L. [4] [5] [12] [19] [20] [21] [22] Eguaras, Sonia [8] Shyam, S. [4] [5] [6] [10] [11] Fito, M. [4] [5] [6] [13] Banos, R. M. [4] [5] [6] [9] Salas-Salvado, J. (Corresponding author) [4] [5] [6] [10] [11] Fernandez-Aranda, Fernando 0000-0002-2968-9898 (Corresponding author) [1] [2] [3] [4] [5] [6]

Affiliations

  1. [1] Hosp Clin Barcelona, Clin Lipids, Endocrinol & Nutr Dept, Inst Invest Biomed August Pi Sunyer IDIBAPS, Barcelona 08036, Spain
    2. [NORA names: Spain; Europe, EU; OECD];
  2. [2] Univ Barcelona, CIBERobn ISCIII, Hosp Univ Bellvitge IDIBELL, Dept Internal Med, E-08007 Barcelona, Spain
    3. [NORA names: Spain; Europe, EU; OECD];
  3. [3] Bellvitge Biomed Res Inst IDIBELL, Neurosci Programme, Psychoneurobiol Eating & Addict Behav Grp, Barcelona, Spain
    4. [NORA names: Spain; Europe, EU; OECD];
  4. [4] Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metab CIBERDEM, Madrid 28029, Spain
    5. [NORA names: Spain; Europe, EU; OECD];
  5. [5] Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
    6. [NORA names: Spain; Europe, EU; OECD];

Abstract

Objectives To examine the cross-sectional association between baseline depressive symptoms and the presence of type 2 diabetes (T2D), and its association with glycated hemoglobin (HbA1c) and other metabolic variables, and the prospective association of depressive symptoms and HbA1c after 1 year of follow-up.Methods n = 6224 Mediterranean older adults with overweight/obesity and metabolic syndrome (48% females, mean age 64.9 +/- 4.9 years) were evaluated in the framework of the PREDIMED-Plus study cohort. Depressive symptoms were assessed using the Beck Depression Inventory-II and HbA1c was used to measure metabolic control.Results The presence of T2D increased the likelihood of higher levels of depressive symptoms (chi(2)= 15.84, p = 0.001). Polynomial contrast revealed a positive linear relationship (chi(2)= 13.49, p = 0.001), the higher the depressive symptoms levels, the higher the prevalence of T2D. Longitudinal analyses showed that the higher baseline depressive symptoms levels, the higher the likelihood of being within the HbA1c >= 7% at 1-year level (Wald-chi(2) = 24.06, df = 3, p < .001, for the full adjusted model). Additionally, depressive levels at baseline and duration of T2D predicted higher HbA1c and body mass index, and lower physical activity and adherence to Mediterranean Diet at 1 year of follow-up.Conclusions This study supports an association between T2D and the severity of depressive symptoms, suggesting a worse metabolic control from mild severity levels in the short-medium term, influenced by lifestyle habits related to diabetes care. Screening for depressive symptoms and a multidisciplinary integrative therapeutic approach should be ensured in patients with T2D.

Keywords

Depressive symptoms, HbA1c, Metabolic syndrome, Severity, Type 2 diabetes

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