open access publication

Article, Early Access, 2024

Risk of subsequent gliomas and meningiomas among 69,460 5-year survivors of childhood and adolescent cancer in Europe: the PanCareSurFup study

BRITISH JOURNAL OF CANCER, ISSN 0007-0920, 0007-0920, 10.1038/s41416-024-02577-y

Contributors

Heymer, Emma J. [1] Hawkins, Michael M. [1] Winter, David L. 0000-0002-1597-4081 [1] Teepen, Jop 0000-0002-2647-2677 [2] Sunguc, Ceren [1] Ronckers, Cecile M. [2] [3] ALLODJI, RODRIGUE 0000-0002-1895-8415 [4] [5] [6] [7] Alessi, Daniela [8] [9] [10] Sugden, Elaine [1] Belle, Fabien N. [11] [12] Bagnasco, Francesca [13] [14] Byrne, J. [15] Bardi, Edit [16] [17] [18] Garwicz, Stanislaw [19] [20] Grabow, Desiree [3] Jankovic, M. [21] Kaatsch, P. [3] Kaiser, Melanie [3] Michel, Gisela [22] Schindera, Christina 0000-0002-4511-287X [12] [23] Haddy, Nadia 0000-0001-9316-8280 [4] [5] [6] [7] Journy, Neige [4] [5] [6] [7] Mazic, Maja Cesen [23] [24] Skinner, Roderick 0000-0002-1162-675X [25] [26] Kok, Judith L. [2] Gunnes, M. [27] [28] Wiebe, Thomas [19] [20] Dugue, P. -A. 0000-0003-2736-3023 [8] [9] [10] Maule, Milena M. [8] [9] [10] Terenziani, Monica [29] Jakab, Zsuzsanna [30] Winther, Jeanette 0000-0002-3440-5108 [31] [32] Lahteenmaki, Paivi M. [33] Zadravec Zaletel, Lorna [32] [34] Haupt, Riccardo [13] [14] Kuehni, Claudia E. [12] [35] Kremer, Leontien C. [2] [36] [37] de Vathaire, Florent [4] [5] [6] [7] Hjorth, Lars 0000-0002-8302-7174 [19] [20] Reulen, Raoul C. (Corresponding author) [1]

Affiliations

  1. [1] Univ Birmingham, Inst Appl Hlth Res, Ctr Childhood Canc Survivor Studies, Birmingham, W Midlands, England
    2. [NORA names: United Kingdom; Europe, Non-EU; OECD];
  2. [2] Princess MAxima Ctr Pediat Oncol, Utrecht, Netherlands
    3. [NORA names: Netherlands; Europe, EU; OECD];
  3. [3] Johannes Gutenberg Univ Mainz, Inst Med Biostat Epidemiol & Informat IMBEI, Div Childhood Canc Epidemiol, German Childhood Canc Registry, Mainz, Germany
    4. [NORA names: Germany; Europe, EU; OECD];
  4. [4] Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth, Radiat Epidemiol Team, INSERM U1018,Gustave Roussy, Villejuif, France
    5. [NORA names: France; Europe, EU; OECD];
  5. [5] Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth, Radiat Epidemiol Team, INSERM U1018,Gustave Roussy, Villejuif, France
    6. [NORA names: France; Europe, EU; OECD];

Abstract

BackgroundChildhood cancer survivors are at risk of subsequent gliomas and meningiomas, but the risks beyond age 40 years are uncertain. We quantified these risks in the largest ever cohort.MethodsUsing data from 69,460 5-year childhood cancer survivors (diagnosed 1940-2008), across Europe, standardized incidence ratios (SIRs) and cumulative incidence were calculated.ResultsIn total, 279 glioma and 761 meningioma were identified. CNS tumour (SIR: 16.2, 95% CI: 13.7, 19.2) and leukaemia (SIR: 11.2, 95% CI: 8.8, 14.2) survivors were at greatest risk of glioma. The SIR for CNS tumour survivors was still 4.3-fold after age 50 (95% CI: 1.9, 9.6), and for leukaemia survivors still 10.2-fold after age 40 (95% CI: 4.9, 21.4). Following cranial radiotherapy (CRT), the cumulative incidence of a glioma in CNS tumour survivors was 2.7%, 3.7% and 5.0% by ages 40, 50 and 60, respectively, whilst for leukaemia this was 1.2% and 1.7% by ages 40 and 50. The cumulative incidence of a meningioma after CRT in CNS tumour survivors doubled from 5.9% to 12.5% between ages 40 and 60, and in leukaemia survivors increased from 5.8% to 10.2% between ages 40 and 50.DiscussionClinicians following up survivors should be aware that the substantial risks of meningioma and glioma following CRT are sustained beyond age 40 and be vigilant for symptoms.

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