open access publication

Article, Early Access, 2024

Antibodies toward Na+,HCO3--cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer

BRITISH JOURNAL OF CANCER, ISSN 0007-0920, 0007-0920, 10.1038/s41416-024-02591-0

Contributors

Axelsen, Trine V. [1] Olesen, Claus [1] Khan, Danish [1] Mohammadi, Ali [1] Bouzinova, Elena V. [1] Nielsen, Christine J. F. [1] Mele, Marco [1] Hauerslev, Katrine R. [1] Pedersen, Helene L. [1] Balling, Eva [1] Vahl, Pernille [1] Tramm, Trine [1] Christiansen, Peer M. [1] Boedtkjer, Ebbe (Corresponding author) [1]

Affiliations

  1. [1] Aarhus Univ Hosp, Dept Pathol, Aarhus, Denmark
    2. [NORA names: AU Aarhus University; University; Denmark; Europe, EU; Nordic; OECD]

Abstract

Background Na+,HCO3--cotransporter NBCn1/Slc4a7 accelerates murine breast carcinogenesis. Lack of specific pharmacological tools previously restricted therapeutic targeting of NBCn1 and identification of NBCn1-dependent functions in human breast cancer.

Data Provider: Clarivate

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