Article, Early Access,
Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19
Affiliations
- [1] Univ Connecticut, Hlth Ctr, Dept Cell Biol, Farmington, CT 06030 USA [NORA names: United States; America, North; OECD];
- [2] Helix Biostruct, Indianapolis, IN USA [NORA names: United States; America, North; OECD];
- [3] Univ Copenhagen, Novo Nord Fdn Ctr Prot Res, Copenhagen, Denmark [NORA names: KU University of Copenhagen; University; Denmark; Europe, EU; Nordic; OECD]
Abstract
Cryo-electron microscopy structures of the PP2A:B55 holoenzyme bound to its inhibitors ARPP19 and FAM122A show distinct binding modes of the two inhibitors.