open access publication

Article, Early Access, 2023

Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19

NATURE, ISSN 0028-0836, 0028-0836, 10.1038/s41586-023-06870-3

Contributors

Padi, Sathish K. R. 0000-0002-5526-4287 [1] Vos, Margaret R. [1] Godek, Rachel J. [1] Fuller, James R. [2] Kruse, Thomas [3] Hein, Jamin B. [3] Nilsson, Jakob [3] Kelker, Matthew S. [2] Page, Rebecca (Corresponding author) [1] Peti, W. (Corresponding author) [1]

Affiliations

  1. [1] Univ Connecticut, Hlth Ctr, Dept Cell Biol, Farmington, CT 06030 USA
    2. [NORA names: United States; America, North; OECD];
  2. [2] Helix Biostruct, Indianapolis, IN USA
    3. [NORA names: United States; America, North; OECD];
  3. [3] Univ Copenhagen, Novo Nord Fdn Ctr Prot Res, Copenhagen, Denmark
    4. [NORA names: KU University of Copenhagen; University; Denmark; Europe, EU; Nordic; OECD]

Abstract

Cryo-electron microscopy structures of the PP2A:B55 holoenzyme bound to its inhibitors ARPP19 and FAM122A show distinct binding modes of the two inhibitors.

Data Provider: Clarivate

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