Article, Early Access,
Effects of sceptical priors on the performance of adaptive clinical trials with binary outcomes.
Affiliations
- [1] Copenhagen Univ Hosp Rigshosp, Dept Intens Care 4131, Blegdamsvej 9, DK-2100 Copenhagen, Denmark [NORA names: KU University of Copenhagen; University; Denmark; Europe, EU; Nordic; OECD];
- [2] Copenhagen Univ Hosp Rigshosp, Dept Intens Care 4131, Blegdamsvej 9, DK-2100 Copenhagen, Denmark [NORA names: Capital Region of Denmark; Hospital; Denmark; Europe, EU; Nordic; OECD];
- [3] Univ Penn, PAIR Palliat & Adv Illness Res Ctr, Perelman Sch Med, Clin Trials Methods & Outcomes Lab, Philadelphia, PA USA [NORA names: United States; America, North; OECD]
Abstract
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Keywords
adaptive trials,
priors,
response-adaptive randomisation,
simulation,
trial design