open access publication

Article, 2024

Structural and mechanistic insights into Quinolone Synthase to address its functional promiscuity

COMMUNICATIONS BIOLOGY, Volume 7, 1, 10.1038/s42003-024-06152-2

Contributors

Vijayanathan, Mallika 0000-0001-9806-3736 [1] [2] [3] Vadakkepat, Abhinav Koyamangalath [4] [5] Mahendran, Kozhinjampara R. 0000-0003-2549-9250 [1] [2] Sharaf, Abdoallah 0000-0002-3436-9290 [6] [7] [8] Frandsen, Kristian E. H. [3] Bandyopadhyay, Debashree [9] Pillai, M. Radhakrishna [1] [2] Soniya, Eppurath Vasudevan (Corresponding author) [1] [2]

Affiliations

  1. [1] Rajiv Gandhi Ctr Biotechnol, Canc Res Program, Thiruvananthapuram 695014, India
    2. [NORA names: India; Asia, South];
  2. [2] Rajiv Gandhi Ctr Biotechnol, Canc Res Program, Thiruvananthapuram 695014, India
    3. [NORA names: India; Asia, South];
  3. [3] Univ Copenhagen, Dept Plant & Environm Sci, DK-1871 Frederiksberg C, Denmark
    4. [NORA names: KU University of Copenhagen; University; Denmark; Europe, EU; Nordic; OECD];
  4. [4] Indian Inst Sci, Mol Biophys Unit, Bangalore, India
    5. [NORA names: India; Asia, South];
  5. [5] Univ Leicester, Dept Mol & Cell Biol, Henry Wellcome Bldg, Lancaster Rd, Leicester LE17HB, Leicestershire, England
    6. [NORA names: United Kingdom; Europe, Non-EU; OECD];

Abstract

A high-resolution structure provides a mechanistic explanation to the synthetic selectivity of quinolone synthase (AmQNS) and possible consequences of functionally relevant residue mutations.

Data Provider: Clarivate

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